UNIVERSITY OF THE PHILIPPINES
College of Arts and Sciences
Institute of Chemistry
CHEM 262
LIPID CHEMISTRY
1st Semester AY 2020-2021
COURSE GUIDE
A. COURSE DETAILS
Course Number: CHEMISTRY 262
Course Title: LIPID CHEMISTRY
Course Description: Structure and Biological Functions, Properties and Applications
Prerequisites: Chemistry 160 or 161a and 161b
Semester offered: First Semester
Credit: 3 units
Number of Hours: 3 hours a week
B. Learning Objectives:
At the end of the course the student should be able to:
1. Discuss the physical and chemical properties and structural features of different classes of lipids and their biological functions.
2. Describe the assembly of membrane compounds and correlate membrane organizations with function.
3. Discuss in detail the biological functions, metabolic regulation and degradation of plasma lipoprotein.
4. Explain and apply the principles and techniques used in lipid and membrane research.
C. Course Outline and Schedule
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The topics to be covered: |
Schedule |
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I. Introduction
II. Classification of Lipids A. Simple Lipids B. complex Lipids |
Sept 10 |
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III. Structure of Lipids A. Fatty acids B. Glycerides (Acyl Glycerol or Neutral Fat) C. Sterols D. Terpenes E. Prostaglandins F. Phosphoglycerides G. Sphingomyelin |
Sept 15- Oct 1 |
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IV. Physical properties A. Fatty Acid-H2O mixture 1. Micellar phase
B. Phospholipid-H2O mixture 1. Lamellar phase a.) Conformation of fatty acid chain b.) Conformation of interface region c.) Conformation of polar head group
2. Molecular motion a.) Rotation about long axis of molecule b.) Lateral diffusion c.) Flip-flop
C. Thermotropic phase transition 1. Nature of phase transition 2. Phase separation 3. Metal ion effects 4. Protein and polypeptide Effects 5. Cholesterol Effects 6. Drug interaction 7. Permeability Characteristics |
Oct 6- Oct 22 |
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EXAM 1 |
Oct 27 |
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V. Lipoproteins A. Types 1. Chylomicrons 2. Very low density lipoproteins (VLDL) 3. Low density lipoproteins (LDL) 4. High density lipoproteins (HDL)
B. Method of separation C. Transport form of metabolic fuel D. Degradation of lipoproteins 1. Enzymatic degradation 2. Utilization of lipids for energy |
Oct 29 – Nov 10 |
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VI. Special Functions of Lipids A. As regulators of enzyme action 1. Modulation of hormone activity 2. Regulation of proteins of the electron transport chain 3. Regulation of carrier protein
B. As molecular components of biological membranes 1. Structural organization of biological membranes 2. State of lipids in biological membranes 3. Mobility of micromolecules |
Nov 12-19 |
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VII. Techniques in Lipid and Membrane Research A. X-ray diffraction B. Electron microscopy C. Radiotracers D. IR and NMR spectroscopy E. HPLC and GLC |
Nov 24- Dec 1 |
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VIII. Advances and Applications A. Biomedical Application B. Nutritional Implication |
Dec 3-8 |
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EXAM 2 |
Dec 10 |
D. MODE OF DELIVERY
The course will be delivered remotely. As a student enrolling in this course, most of the time, you will be studying on your own. Classes will be conducted asynchronously in our course site, which is the Elbi (e-learning Based Instruction). The course site can be accessed through this link http://ilcecourses.uplb.edu.ph . Login using your UP mail credentials. If you do not have access yet, contact ilc.uplb@up.edu.ph. Elbi can also be accessed using the Moodle app. All forms of learning materials (modules, study guides, quizzes, and others) will be uploaded in this site. An alternative learning management site (LMS) like Google Classroom or Edmodo will also be created by the lecturer/lecture partner. This alternative LMS will be used in case Elbi is problematic or cannot be accessed.
Most of the time, the class will be conducted using the synchronous mode of teaching. The session may be conducted through Zoom or other video conferencing app, during a consensually agreed upon time, which may not necessarily be the same as the SAIS schedule of this course. If agreed upon by everybody, the session will be recorded and the recording will be shared to you and the rest of the class, for later or repeated viewing.
E. COURSE MATERIALS
The course materials in your course include:
1. Course guide
2. Study guide/module per topic
3. Learning resources (usually embedded in the study guide)
4. Examples/activity guides/self-assessment quizzes (if not embedded in study guide)
F. COURSE REQUIREMENTS
Grading System
2 Long exams 60%
2 Oral Reports 40%
Total 100%
G. HOUSE RULES
1. Attendance will be monitored, so make it to a point to visit the course site from time to time, especially during our class schedule. Also, by always visiting our course site, you will be on track to the progress of our lesson.
2. Remember the following important values:
· Honor intellectual property rights – Do not share any materials from this course! We teachers are doing extra effort to make this course pack available to you. The materials in this course are made available to you solely for academic purposes. Since you do not take part in the making of these materials, you are not allowed to share these to anyone by any means (especially online repository of materials).
· Cheating is a no no! You are a UP student. Always remember, “Honor and Excellence”. What is excellence when you do not have honor? Resist the temptation of any forms of cheating in all assessment types. The assessment is a gauge of how you have learned the topics. Looking into your notes/books or texting your classmates for answers defeats that purpose. The lecturer is willing to put that extra help to get you through this, especially in this trying time. Disciplinary measures/actions await to those who are caught.
· We do not tolerate plagiarism! You already know how to paraphrase sentences in your English class, so why plagiarize? Disciplinary measures/actions await to those who are caught.
5. For unavoidable circumstances (health and other concerns), do not hesitate to contact your lecturer.
6. Enjoy the course!